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1

History of gene therapy

Wirth, Thomas, Parker, Nigel, Ylä-Herttuala, Seppo

Journal:

Year:

2013

Language:

english

File:

PDF, 865 KB

english, 2013

2

Gene Editing of Human Embryos with CRISPR/Cas9: Great Promise Coupled with Important Caveats

Schenkwein, Diana, Ylä-Herttuala, Seppo

Journal:

Molecular Therapy

Year:

2018

Language:

english

File:

PDF, 120 KB

english, 2018

3

Transcriptional Profiling of Hypoxia-Regulated Non-coding RNAs in Human Primary Endothelial Cells

Moreau, Pierre R., Örd, Tiit, Downes, Nicholas L., Niskanen, Henri, Bouvy-Liivrand, Maria, Aavik, Einari, Ylä-Herttuala, Seppo, Kaikkonen, Minna U.

Journal:

Frontiers in Cardiovascular Medicine

Year:

2018

Language:

english

File:

PDF, 2.82 MB

english, 2018

4

Adverse effects of gene therapy: Hero or villain?

Ylä-Herttuala, S

Journal:

Year:

2003

Language:

english

File:

PDF, 59 KB

english, 2003

5

Recent Advancements in Cardiovascular Gene Therapy and Vascular Biology

Laakkonen, Johanna, Ylä-Herttuala, Seppo

Journal:

Human Gene Therapy

Year:

2015

Language:

english

File:

PDF, 286 KB

english, 2015

6

CMR 2005: 12.06: Ultra-small iron oxide nanoparticle (USPIO)-labeled baculoviruses as novel MRI agents for imaging viral vector biodistribution in vivo

J. Hakumäki, J. Räty, T. Wirth, T. Huhtala, T. Ihalainen, M. Vihinen-Ranta, A. Närvänen, S. Ylä-Herttuala

Journal:

Contrast Media & Molecular Imaging

Year:

2006

Language:

english

File:

PDF, 54 KB

english, 2006

7

Generation of lentivirus vectors using recombinant baculoviruses

Lesch, H P, Turpeinen, S, Niskanen, E A, Mähönen, A J, Airenne, K J, Ylä-Herttuala, S

Journal:

Year:

2008

Language:

english

File:

PDF, 282 KB

english, 2008

8

Epigenetics and atherosclerosis

Mikko P. Turunen, Einari Aavik, Seppo Ylä-Herttuala

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2009

Language:

english

File:

PDF, 481 KB

english, 2009

9

Postmenopausal hormone replacement therapy and autoantibodies against oxidized LDL

Anna-Mari Heikkinen, Leo Niskanen, Seppo Ylä-Herttuala, Jukka Luoma, Marjo T. Tuppurainen, Marja Komulainen, Seppo Saarikoski

Journal:

Year:

1998

Language:

english

File:

PDF, 84 KB

english, 1998

10

Avidin-biotin technology in targeted therapy

Lesch, Hanna P, Kaikkonen, Minna U, Pikkarainen, Jere T, Ylä-Herttuala, Seppo

Journal:

Expert Opinion on Drug Delivery

Year:

2010

Language:

english

File:

PDF, 625 KB

english, 2010

11

Hyperbaric oxygen therapy activates hypoxia-inducible factor 1 (HIF-1), which contributes to improved wound healing in diabetic mice

Sunkari, Vivekananda Gupta, Lind, Folke, Botusan, Ileana Ruxandra, Kashif, Abad, Liu, Zhao-Jun, Ylä-Herttuala, Seppo, Brismar, Kerstin, Velazquez, Omaida, Catrina, Sergiu-Bogdan

Journal:

Wound Repair and Regeneration

Year:

2015

Language:

english

File:

PDF, 765 KB

english, 2015

12

Growth Factor Therapy and Autologous Lymph Node Transfer in Lymphedema

Lahteenvuo, M., Honkonen, K., Tervala, T., Tammela, T., Suominen, E., Lahteenvuo, J., Kholova, I., Alitalo, K., Yla-Herttuala, S., Saaristo, A.

Journal:

Year:

2011

Language:

english

File:

PDF, 5.40 MB

english, 2011

13

Autoantibodies Against Oxidized Low Density Lipoprotein in Patients With Angiographically Verified Coronary Artery Disease

Lehtimaki, T., Lehtinen, S., Solakivi, T., Nikkila, M., Jaakkola, O., Jokela, H., Yla-Herttuala, S., Luoma, J. S., Koivula, T., Nikkari, T.

Journal:

Arteriosclerosis Thrombosis and Vascular Biology

Year:

1999

Language:

english

File:

PDF, 545 KB

english, 1999

14

Call for papers: Nanoparticle Development and Applications in Cellular and Molecular Therapies

Frederickson, Robert M., Moghimi, SM, Wagner, E, Yla-Herttuala, Seppo

Journal:

Molecular Therapy

Year:

2016

Language:

english

File:

PDF, 309 KB

english, 2016

15

ADA-SCID Gene Therapy Endorsed By European Medicines Agency For Marketing Authorization

Ylä-Herttuala, Seppo

Journal:

Molecular Therapy

Year:

2016

Language:

english

File:

PDF, 190 KB

english, 2016

16

ADVANCES AND CHALLENGES IN CARDIOVASCULAR GENE THERAPY

Ylä-Herttuala, Seppo, Lähteenvuo, Johanna

Journal:

Human Gene Therapy

Year:

2017

Language:

english

File:

PDF, 981 KB

english, 2017

17

Gene Therapy: The First Approved Gene-Based Medicines, Molecular Mechanisms and Clinical Indications

Raty, J., Pikkarainen, J., Wirth, T., Yla-Herttuala, S.

Journal:

Current Molecular Pharmacology

Year:

2008

Language:

english

File:

PDF, 390 KB

english, 2008

18

Therapeutic effects of rosuvastatin in hypercholesterolemic prediabetic mice in the absence of low density lipoprotein receptor

Gurzeler, Erika, Aavik, Einari, Laine, Anssi, Valkama, Teemu, Niskanen, Henri, Huusko, Jenni, Kaikkonen, Minna U., Ylä-Herttuala, Seppo

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2018

Language:

english

File:

PDF, 18.54 MB

english, 2018

19

Release of replication-deficient retroviruses from a packaging cell line: Interaction with glioma tumor spheroids in vitro

Frits Thorsen, Therese Visted, Paulina Lehtolainen, Seppo Ylä-Herttuala, Rolf Bjerkvig

Journal:

International Journal of Cancer

Year:

1997

Language:

english

File:

PDF, 267 KB

english, 1997

20

lacZ-neoR transfected glioma cells in syngeneic rats: Growth pattern and characterization of the host immune response against cells transplanted inside and outside the cns

Therese Visted, Jon Thorsen, Frits Thorsen, Tracy-Ann Read, Elling Ulvestad, Olav Engebraaten, Dag Sørensen, Seppo Ylä-Herttuala, Kristina Tyynela, Garry Rucklidge, Klaus Edvardsen, Rolf Bjerkvig, Mor

Journal:

International Journal of Cancer

Year:

2000

Language:

english

File:

PDF, 626 KB

english, 2000

21

Periadventitial lacZ gene transfer to pig carotid arteries using a biodegradable collagen collar or a wrap of collagen sheet with adenoviruses and plasmid–liposome complexes

Timo M. Pakkanen, Marja Laitinen, Mikko Hippeläinen, Mikko O. Hiltunen, Esko Alhava, Seppo Ylä-Herttuala

Journal:

The Journal of Gene Medicine

Year:

2000

Language:

english

File:

PDF, 794 KB

english, 2000

22

Sequential acetaldehyde production, lipid peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease

Onni Nlemelä, Seppo Parkkila, Seppo Ylä-herttuala, Jesus Villanueva, Boris Ruebner, Charles H. Halsted

Journal:

Year:

1995

Language:

english

File:

PDF, 823 KB

english, 1995

23

Genetic alterations in the peritumoral stromal cells of malignant and borderline epithelial ovarian tumors as indicated by allelic imbalance on chromosome 3p

Hanna Tuhkanen, Maarit Anttila, Veli-Matti Kosma, Seppo Ylä-Herttuala, Seppo Heinonen, Arja Kuronen, Matti Juhola, Raija Tammi, Markku Tammi, Arto Mannermaa

Journal:

International Journal of Cancer

Year:

2004

Language:

english

File:

PDF, 366 KB

english, 2004

24

Endostatin inhibits endochondral ossification

A. Sipola, J. Ilvesaro, E. Birr, P. Jalovaara, R. F. Pettersson, F. Stenbäck, S. Ylä-Herttuala, T. Hautala, J. Tuukkanen

Journal:

The Journal of Gene Medicine

Year:

2007

Language:

english

File:

PDF, 601 KB

english, 2007

25

The administration of an adenoviral thymidine kinase suicide gene to the uterine artery of rabbits does not affect fertility: a safety study of pregnant and nonpregnant rabbits and their offspring

Anniina Laurema, Mervi Riekkinen, Tommi Heikura, Elisa Vähäkangas, Hannu Manninen, Seppo Heinonen, Seppo Ylä-Herttuala

Journal:

The Journal of Gene Medicine

Year:

2008

Language:

english

File:

PDF, 227 KB

english, 2008

26

Baculovirus is an efficient vector for the transduction of the eye: comparison of baculovirus- and adenovirus-mediated intravitreal vascular endothelial growth factor D gene transfer in the rabbit eye

Kati Kinnunen, Giedrius Kalesnykas, Anssi J. Mähönen, Svetlana Laidinen, Liisa Holma, Tommi Heikura, Kari Airenne, Hannu Uusitalo, Seppo Ylä-Herttuala

Journal:

The Journal of Gene Medicine

Year:

2009

Language:

english

File:

PDF, 348 KB

english, 2009

27

A preclinical assessment of the safety and biodistribution of an adenoviral vector containing the herpes simplex virus thymidine kinase gene (Cerepro®) after intracerebral administration

Gillian Langford, Anthony Dayan, Seppo Yla-Herttuala, David Eckland

Journal:

The Journal of Gene Medicine

Year:

2009

Language:

english

File:

PDF, 476 KB

english, 2009

28

Optimized in situ PCR method for the detection of gene transfer vector in histological sections

Pia M. Leppänen, Jonna Koponen, Mikko P. Turunen, Timo Pakkanen, Seppo Ylä-Herttuala

Journal:

The Journal of Gene Medicine

Year:

2001

Language:

english

File:

PDF, 435 KB

english, 2001

29

Baculovirus-mediated vascular endothelial growth factor-DΔNΔC gene transfer induces angiogenesis in rabbit skeletal muscle

Tommi Heikura, Tiina Nieminen, Miia M. Roschier, Henna Karvinen, Minna U. Kaikkonen, Anssi J. Mähönen, Hanna P. Lesch, Tuomas T. Rissanen, Olli H. Laitinen, Kari J. Airenne, Seppo Ylä-Herttuala

Journal:

The Journal of Gene Medicine

Year:

2012

Language:

english

File:

PDF, 483 KB

english, 2012

30

EC-SOD gene therapy reduces paracetamol-induced liver damage in mice

Mikko O. Laukkanen, Pia Leppanen, Paivi Turunen, Tiina Tuomisto, Jonne Naarala, Seppo Yla-Herttuala

Journal:

The Journal of Gene Medicine

Year:

2001

Language:

english

File:

PDF, 259 KB

english, 2001

31

The use of low-molecular-weight PEIs as gene carriers in the monkey fibroblastoma and rabbit smooth muscle cell cultures

Pasi Lampela, Johanna Räisänen, Pekka T. Männistö, Seppo Ylä-Herttuala, Atso Raasmaja

Journal:

The Journal of Gene Medicine

Year:

2002

Language:

english

File:

PDF, 303 KB

english, 2002

32

Evaluation of angiogenesis and side effects in ischemic rabbit hindlimbs after intramuscular injection of adenoviral vectors encoding VEGF and LacZ

Ismo Vajanto, Tuomas T. Rissanen, Juha Rutanen, Mikko O. Hiltunen, Tiina T. Tuomisto, Katja Arve, Outi Närvänen, Hannu Manninen, Heikki Räsänen, Mikko Hippeläinen, Esko Alhava, Seppo Ylä-Herttuala

Journal:

The Journal of Gene Medicine

Year:

2002

Language:

english

File:

PDF, 450 KB

english, 2002

33

Adenoviral VEGF-A gene transfer induces angiogenesis and promotes bone formation in healing osseous tissues

Tatu Tarkka, Annina Sipola, Timo Jämsä, Ylermi Soini, Seppo Ylä-Herttuala, Juha Tuukkanen, Dr Timo Hautala

Journal:

The Journal of Gene Medicine

Year:

2003

Language:

english

File:

PDF, 348 KB

english, 2003

34

Stable RNA interference: comparison of U6 and H1 promoters in endothelial cells and in mouse brain

Petri I. Mäkinen, Jonna K. Koponen, Anna-Mari Kärkkäinen, Tarja M. Malm, Kati H. Pulkkinen, Jari Koistinaho, Mikko P. Turunen, Seppo Ylä-Herttuala

Journal:

The Journal of Gene Medicine

Year:

2006

Language:

english

File:

PDF, 536 KB

english, 2006

35

Type I interferon response against viral and non-viral gene transfer in human tumor and primary cell lines

Outi Rautsi, Saara Lehmusvaara, Tuula Salonen, Katja Häkkinen, Maarit Sillanpää, Tanja Hakkarainen, Sami Heikkinen, Elisa Vähäkangas, Seppo Ylä-Herttuala, Ari Hinkkanen, Ilkka Julkunen, Jarmo Wahlfors

Journal:

The Journal of Gene Medicine

Year:

2007

Language:

english

File:

PDF, 1.21 MB

english, 2007

36

Water diffusion in a rat glioma during ganciclovir-thymidine kinase gene therapy-induced programmed cell death in vivo: Correlation with cell density

Piia K. Valonen, Kimmo K. Lehtimäki, Tuula H. Väisänen, Mikko I. Kettunen, Olli H.J. Gröhn, Seppo Ylä-Herttuala, Risto A. Kauppinen

Journal:

Journal of Magnetic Resonance Imaging

Year:

2004

Language:

english

File:

PDF, 503 KB

english, 2004

37

Targeted magnetic resonance imaging of Scavidin-receptor in human umbilical vein endothelial cells in vitro

Tuomas Mäntylä, Juhana M. Hakumäki, Tuulia Huhtala, Ale Närvänen, Seppo Ylä-Herttuala

Journal:

Magnetic Resonance in Medicine

Year:

2006

Language:

english

File:

PDF, 383 KB

english, 2006

38

Water spin dynamics during apoptotic cell death in glioma gene therapy probed by T1ρ and T2ρ

A. Sierra, S. Michaeli, J.-P. Niskanen, P.K. Valonen, H.I. Gröhn, S. Ylä-Herttuala, M. Garwood, O.H. Gröhn

Journal:

Magnetic Resonance in Medicine

Year:

2008

Language:

english

File:

PDF, 1.05 MB

english, 2008

39

1H MR spectroscopic imaging of phospholipase-mediated membrane lipid release in apoptotic rat glioma in vivo

Timo J. Liimatainen, Arja T. Erkkilä, Piia Valonen, Helvi Vidgren, Merja Lakso, Garry Wong, Olli H.J. Gröhn, Seppo Ylä-Herttuala, Juhana M. Hakumäki

Journal:

Magnetic Resonance in Medicine

Year:

2008

Language:

english

File:

PDF, 617 KB

english, 2008

40

Glioma cell density in a rat gene therapy model gauged by water relaxation rate along a fictitious magnetic field

Timo Liimatainen, Alejandra Sierra, Timothy Hanson, Dennis J. Sorce, Seppo Ylä-Herttuala, Michael Garwood, Shalom Michaeli, Olli Gröhn

Journal:

Magnetic Resonance in Medicine

Year:

2012

Language:

english

File:

PDF, 2.16 MB

english, 2012

41

Vascular endothelial growth factor (VEGF) gene transfer enhances surgical revascularization of necrotic bone

Kosuke Katsube, Allen T. Bishop, Robert D. Simari, Seppo Ylä-Herttuala, Patricia F. Friedrich

Journal:

Journal of Orthopaedic Research

Year:

2005

Language:

english

File:

PDF, 757 KB

english, 2005

42

Culture medium induced vimentin reorganization associates with enhanced baculovirus-mediated gene delivery

Anssi J. Mähönen, Kaisa-Emilia Makkonen, Johanna P. Laakkonen, Teemu O. Ihalainen, Sari P. Kukkonen, Minna U. Kaikkonen, Maija Vihinen-Ranta, Seppo Ylä-Herttuala, Kari J. Airenne

Journal:

Journal of Biotechnology

Year:

2010

Language:

english

File:

PDF, 1.72 MB

english, 2010

43

Baseline Diene Conjugation in LDL Lipids as a Direct Measure of In Vivo LDL Oxidation

Markku Ahotupa, Jukka Marniemi, Terho Lehtimäki, Kati Talvinen, Olli T. Raitakari, Tommi Vasankari, Jorma Viikari, Jukka Luoma, Seppo Ylä-Herttuala

Journal:

Clinical Biochemistry

Year:

1998

Language:

english

File:

PDF, 167 KB

english, 1998

44

Gene therapy for therapeutic angiogenesis in critically ischaemic lower limb – on the way to the clinic

T. T. Rissanen, I. Vajanto, S. Ylä-Herttuala

Journal:

European Journal of Clinical Investigation

Year:

2001

Language:

english

File:

PDF, 165 KB

english, 2001

45

TAFFEL: Independent Enrichment Analysis of gene sets

Mitja I Kurki, Jussi Paananen, Markus Storvik, Seppo Ylä-Herttuala, Juha E Jääskeläinen, Mikael von und zu Fraunberg, Garry Wong, Petri Pehkonen

Journal:

BMC Bioinformatics

Year:

2011

Language:

english

File:

PDF, 1.81 MB

english, 2011

46

Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice

Suvi E Heinonen, Mari Merentie, Marja Hedman, Petri I Mäkinen, Elina Loponen, Ivana Kholová, Fatima Bosch, Markku Laakso, Seppo Ylä-Herttuala

Journal:

Cardiovascular Diabetology

Year:

2011

Language:

english

File:

PDF, 6.85 MB

english, 2011

47

Human gene therapy and imaging: cardiology

Joseph C. Wu, Seppo Yla-Herttuala

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Year:

2005

Language:

english

File:

PDF, 587 KB

english, 2005

48

Non-specific binding of [18F]FDG to calcifications in atherosclerotic plaques: experimental study of mouse and human arteries

Iina Laitinen, Päivi Marjamäki, Merja Haaparanta, Nina Savisto, V. Jukka O. Laine, Sanna L. Soini, Ian Wilson, Pia Leppänen, Seppo Ylä-Herttuala, Anne Roivainen, Juhani Knuuti

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Year:

2006

Language:

english

File:

PDF, 291 KB

english, 2006

49

Uptake of inflammatory cell marker [11C]PK11195 into mouse atherosclerotic plaques

Iina Laitinen, Päivi Marjamäki, Kjell Någren, V. Jukka O. Laine, Ian Wilson, Pia Leppänen, Seppo Ylä-Herttuala, Anne Roivainen, Juhani Knuuti

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Year:

2009

Language:

english

File:

PDF, 459 KB

english, 2009

50

Macrophages, smooth muscle cells, endothelial cells, and T-cells express CD40 and CD40L in fatty streaks and more advanced human atherosclerotic lesions

T. Häkkinen, K. Karkola, S. Ylä-Herttuala

Journal:

Virchows Archiv

Year:

2000

Language:

english

File:

PDF, 1.09 MB

english, 2000